Paper card · curated
Improvement of cognitive functions by oral intake of Hericium erinaceus
Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K
Biomedical Research · 2019
Abstract excerpt
Double-blind placebo-controlled trial in 31 healthy Japanese adults aged 50-80 receiving 3.2 g/day of lion's mane fruit body powder for 12 weeks. Cognitive endpoints (working memory, visuospatial reasoning) showed measurable improvement vs placebo over the dosing period. The dose used here is approximately 4× the dose in Mori 2009 and confirms the cognitive signal in a non-MCI population, though the sample size remains modest.
Excerpt from the published abstract. Full paper at the journal link below.
Joe's notes
How to read this paper
Companion to Mori 2009. Note the dose: 3.2 g/day of fruit-body powder is a meaningful dose; most consumer-grade supplements at 250-500 mg/day are well below this level. If you're matching what the literature did, dose accordingly.
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Research papers in this library describe published scientific findings. They are not therapeutic claims. These statements have not been evaluated by the FDA. Compounds discussed in any paper are not intended to diagnose, treat, cure, or prevent any disease. Talk to a healthcare provider before making decisions about supplements.