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Compounds, history, science.
Long-form articles on the science of mushroom medicine. Every claim links to peer-reviewed literature. We're not interested in hype — we want you to understand the actual chemistry, mechanism, and dose ranges that the published research supports.
Featured articles
CBD vs CBDA — why the molecular form matters
Most CBD products are sold as CBD. The hemp plant doesn't make CBD — it makes CBDA, which decarboxylates to CBD when heated. Understanding the difference matters for dose, absorption, and what the published research actually measured.
9 min read · 4 citations
Apr 15, 2026
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Hericenones + erinacines — what makes lion's mane unique
Lion's mane (Hericium erinaceus) contains two compound families nearly absent from any other organism: hericenones in the fruit body, erinacines in the mycelium. Both have been shown in vitro to induce nerve growth factor (NGF) expression. This is the actual basis for lion's mane's reputation in cognitive support.
11 min read · 5 citations
Apr 12, 2026
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Beta-glucans, dectin-1, and the actual immunology of medicinal mushrooms
The vague claim 'mushrooms boost the immune system' has actual receptor-level mechanism behind it. Beta-glucans bind to dectin-1 on macrophages, triggering measurable immune cascades. Here's the science, and how to read product labels with that knowledge.
10 min read · 5 citations
Apr 8, 2026
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The psychedelic legal landscape — where things stand in 2026
Psilocybin, MDMA, ketamine, and related compounds occupy a fragmented legal space — federally Schedule I, but with state-level decriminalization, FDA Breakthrough Designation, and active clinical trials. Here's the actual current state of regulation, and what's hypothetically next.
12 min read · 5 citations
Apr 5, 2026
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5,000 years of mushroom medicine — a brief, accurate history
Reishi (Ganoderma) was documented in the Shennong Ben Cao Jing (28-220 CE). The Ötzi the Iceman (5,300 years ago) carried birch polypore. The historical record is much deeper than the recent 'functional mushroom' boom suggests — and the science is finally catching up to what traditional medicine systems had already mapped out.
10 min read · 6 citations
Apr 1, 2026
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