Paper card · curated
Hericenones C, D, E, stimulators of nerve growth factor synthesis from the mushroom Hericium erinaceus
Kawagishi H, Ando M, Sakamoto H, Yoshida S, Ojima F, et al.
Tetrahedron Letters · 1991
Abstract excerpt
Three novel compounds, hericenones C, D, and E, were isolated from the dried fruit body of Hericium erinaceus. All three induce nerve growth factor (NGF) synthesis in cultured astrocytes at low concentrations. The structural characterization establishes hericenones as a class of cyathane-type diterpenoids; mechanism for NGF induction is consistent with selective signaling-pathway activation rather than direct cytotoxic stress.
Excerpt from the published abstract. Full paper at the journal link below.
Joe's notes
How to read this paper
The discovery paper for the hericenone class. Worth reading even if you only skim the structures — establishes that lion's mane fruit body produces compounds with documented NGF-inducing activity. Subsequent literature builds from here.
Read the paper
FDA disclaimer
Research papers in this library describe published scientific findings. They are not therapeutic claims. These statements have not been evaluated by the FDA. Compounds discussed in any paper are not intended to diagnose, treat, cure, or prevent any disease. Talk to a healthcare provider before making decisions about supplements.