Paper card · curated
Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment
Englund A, Morrison PD, Nottage J, Hague D, Kane F, et al.
Journal of Psychopharmacology · 2013
Abstract excerpt
Double-blind randomized controlled trial in 48 healthy male volunteers comparing pretreatment with 600 mg oral CBD vs placebo before intravenous THC (1.5 mg). CBD pretreatment significantly reduced THC-induced paranoid symptoms and prevented THC-induced hippocampal-dependent memory impairment. The findings provide controlled human evidence for the entourage-effect hypothesis: CBD modulates THC's adverse psychoactive effects without abolishing the psychoactive experience.
Excerpt from the published abstract. Full paper at the journal link below.
Joe's notes
How to read this paper
The strongest controlled-trial evidence for what's casually called the 'entourage effect' between THC and CBD. Note the doses used: 600 mg oral CBD is far above wellness-product dosing; the study can't tell you whether 25 mg/day full-spectrum has the same effect.
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